Exercise interventions for older adults: A systematic review of meta-analyses     

Claudio Di Lorito  Annabelle Long  Adrian Byrne  Rowan H. Harwood  John R.F. Gladman  Stefan Schneider  Pip Logan  Alessandro Bosco  Veronika van der Wardt 《运动与健康科学(英文)》2021,10(1):29

BackgroundThe evidence concerning which physical exercise characteristics are most effective for older adults is fragmented. We aimed to characterize the extent of this diversity and inconsistency and identify future directions for research by undertaking a systematic review of meta-analyses of exercise interventions in older adults.MethodsWe searched the Cochrane Database of Systematic Reviews, PsycInfo, MEDLINE, Embase, CINAHL, AMED, SPORTDiscus, and Web of Science for articles that met the following criteria: (1) meta-analyses that synthesized measures of improvement (e.g., effect sizes) on any outcome identified in studies of exercise interventions; (2) participants in the studies meta-analyzed were adults aged 65+ or had a mean age of 70+; (3) meta-analyses that included studies of any type of exercise, including its duration, frequency, intensity, and mode of delivery; (4) interventions that included multiple components (e.g., exercise and cognitive stimulation), with effect sizes that were computed separately for the exercise component; and (5) meta-analyses that were published in any year or language. The characteristics of the reviews, of the interventions, and of the parameters improved through exercise were reported through narrative synthesis. Identification of the interventions linked to the largest improvements was carried out by identifying the highest values for improvement recorded across the reviews. The study included 56 meta-analyses that were heterogeneous in relation to population, sample size, settings, outcomes, and intervention characteristics.ResultsThe largest effect sizes for improvement were found for resistance training, meditative movement interventions, and exercise-based active videogames.ConclusionThe review identified important gaps in research, including a lack of studies investigating the benefits of group interventions, the characteristics of professionals delivering the interventions associated with better outcomes, and the impact of motivational strategies and of significant others (e.g., carers) on intervention delivery and outcomes.  相似文献   

Microfluidic-driven viral infection on cell cultures: Theoretical and experimental study     

Elisa Cimetta  Mauro Franzoso  Marta Trevisan  Elena Serena  Alessandro Zambon  Stefano Giulitti  Luisa Barzon  Nicola Elvassore 《Biomicrofluidics》2012,6(2):024127-12

Advanced cell culture systems creating a controlled and predictable microenvironment together with computational modeling may be useful tools to optimize the efficiency of cell infections. In this paper, we will present a phenomenological study of a virus-host infection system, and the development of a multilayered microfluidic platform used to accurately tune the virus delivery from a diffusive-limited regime to a convective-dominated regime. Mathematical models predicted the convective-diffusive regimes developed within the system itself and determined the dominating mass transport phenomena. Adenoviral vectors carrying the enhanced green fluorescent protein (EGFP) transgene were used at different multiplicities of infection (MOI) to infect multiple cell types, both in standard static and in perfused conditions. Our results validate the mathematical models and demonstrate how the infection processes through perfusion via microfluidic platform led to an enhancement of adenoviral infection efficiency even at low MOIs. This was particularly evident at the longer time points, since the establishment of steady-state condition guaranteed a constant viral concentration close to cells, thus strengthening the efficiency of infection. Finally, we introduced the concept of effective MOI, a more appropriate variable for microfluidic infections that considers the number of adenoviruses in solution per cell at a certain time.  相似文献   

Polyester μ-assay chip for stem cell studies     

Francesco Piraino  ?eila Selimovi?  Marco Adamo  Alessandro Pero  Sam Manoucheri  Sang Bok Kim  Danilo Demarchi  Ali Khademhosseini 《Biomicrofluidics》2012,6(4)

The application of microfluidic technologies to stem cell research is of great interest to biologists and bioengineers. This is chiefly due to the intricate ability to control the cellular environment, the reduction of reagent volume, experimentation time and cost, and the high-throughput screening capabilities of microscale devices. Despite this importance, a simple-to-use microfluidic platform for studying the effects of growth factors on stem cell differentiation has not yet emerged. With this consideration, we have designed and characterized a microfluidic device that is easy to fabricate and operate, yet contains several functional elements. Our device is a simple polyester-based microfluidic chip capable of simultaneously screening multiple independent stem cell culture conditions. Generated by laser ablation and stacking of multiple layers of polyester film, this device integrates a 10 × 10 microwell array for cell culture with a continuous perfusion system and a non-linear concentration gradient generator. We performed numerical calculations to predict the gradient formation and calculate the shear stress acting on the cells inside the device. The device operation was validated by culturing murine embryonic stem cells inside the microwells for 5 days. Furthermore, we showed the ability to maintain the pluripotency of stem cell aggregates in response to concentrations of leukemia inhibitory factor ranging from 0 to ∼1000 U/ml. Given its simplicity, fast manufacturing method, scalability, and the cell-compatible nature of the device, it may be a useful platform for long-term stem cell culture and studies.  相似文献   

Global real-time optimization by output-feedback extremum-seeking control with sliding modes     

Tiago Roux Oliveira  Alessandro Jacoud Peixoto  Liu Hsu 《Journal of The Franklin Institute》2012,349(4):1397-1415

This paper addresses the design of a sliding mode based extremum-seeking controller for a class of single-input–single-output (SISO) uncertain nonlinear systems with unmatched and state-dependent strong nonlinearities. We demonstrate that it is possible to achieve an arbitrarily small neighborhood of the desired optimal point using only output-feedback. The key idea is the combination of a periodic switching function with a norm state observer. As an important advantage, we show that the proposed scheme achieves extremum-seeking for all initial conditions, i.e., the real-time optimization algorithm has global convergence properties. An application to a simple nonderivative optimizer illustrates the viability of the proposed approach.  相似文献   

Social Cognition,Language, and Prosocial Behaviors: A Multitrait Mixed-Methods Study in Early Childhood     

Elisabetta Conte  Ilaria Grazzani  Alessandro Pepe 《Early education and development》2018,29(6):814-830

Research Findings: In this study, we investigated associations among social cognition skills (specifically, emotion knowledge and theory of mind), language abilities, and 3 varieties of prosocial behavior (helping, sharing, and comforting) in early childhood. The effects of age and gender were also taken into account. Participants were 149 Italian children between 24 and 47 months of age (M = 35.6 months, SD = 6.77 months). We adopted a multitrait mixed-methods research design, using direct measures of emotion knowledge, theory of mind, and language as well as naturalistic observations of children’s free play with peers to detect the frequency with which they engaged in prosocial behaviors. Ordinal logistic regression analyses showed that helping behaviors were especially accounted for by emotion knowledge and gender, whereas variance in sharing behaviors was mostly explained by theory-of-mind ability and language. Practice or Policy: The findings encourage those involved in early childhood education to develop training and intervention programs to enhance children’s emotional, linguistic, and cognitive skills. Given that these results were obtained with children as young as 2 and 3 years, preventive intervention should be implemented during the earliest years of life.  相似文献   

Physiological intensity profile,exercise load and performance predictors of a 65-km mountain ultra-marathon     

Alessandro Fornasiero  Aldo Savoldelli  Damiano Fruet  Gennaro Boccia  Barbara Pellegrini  Federico Schena 《Journal of sports sciences》2018,36(11):1287-1295

The aims of the study were to describe the physiological profile of a 65-km (4000-m cumulative elevation gain) running mountain ultra-marathon (MUM) and to identify predictors of MUM performance. Twenty-three amateur trail-runners performed anthropometric evaluations and an uphill graded exercise test (GXT) for VO_2max, ventilatory thresholds (VTs), power outputs (PMax, PVTs) and heart rate response (HRmax, HR@VTs). Heart rate (HR) was monitored during the race and intensity was expressed as: Zone I (VT2) for exercise load calculation (training impulse, TRIMP). Mean race intensity was 77.1%±4.4% of HRmax distributed as: 85.7%±19.4% Zone I, 13.9%±18.6% Zone II, 0.4%±0.9% Zone III. Exercise load was 766±110 TRIMP units. Race time (11.8±1.6h) was negatively correlated with VO_2max (r = ?0.66, P <0.001) and PMax (r = ?0.73, P <0.001), resulting these variables determinant in predicting MUM performance, whereas exercise thresholds did not improve performance prediction. Laboratory variables explained only 59% of race time variance, underlining the multi-factorial character of MUM performance. Our results support the idea that VT1 represents a boundary of tolerable intensity in this kind of events, where exercise load is extremely high. This information can be helpful in identifying optimal pacing strategies to complete such extremely demanding MUMs.  相似文献   

Energetic demand and physical conditioning of table tennis players. A study review     

Alessandro Moura Zagatto  Miran Kondric  Beat Knechtle  Pantelis Theo Nikolaidis  Billy Sperlich 《Journal of sports sciences》2018,36(7):724-731

Table tennis is a racket sport characterised by an intermittent movement profile, including short rallies interspersed with short breaks. In contrast to other racket sports, information is lacking regarding the: (i) physiological responses during table tennis matches and training; and (ii) practical recommendations for enhancing aerobic and anaerobic performance in table tennis by improving cardio-metabolic and neuro-muscular fitness, anthropometry and nutritional strategies. Therefore, this review article attempts to narratively provide an overview of the physiology of table tennis by describing the metabolic mechanisms underlying match play and outlining a framework for practical recommendations for improving cardio-metabolic and neuro-muscular fitness, anthropometry as well as nutritional strategies. A second aim was to stimulate future research on table tennis and to point out study limitations in this context. In general, the most important finding is that the rally duration is short at around 3.5s, with a longer rest time of around 8–20s, resulting in an effort-rest ratio ranging from 0.15 to 0.22 in official matches and energetic demands during match relatively low. Future studies should focus on the relationship between energetic demand and table tennis performance with a view to predicting performance in table tennis using physiological parameters.  相似文献   

Chemical analyses of ancient glass findings excavated in the Venetian lagoon     

Marco Verit  Alessandro Renier  Sandro Zecchin 《Journal of Cultural Heritage》2002,3(4):521

Although Venice is regarded as being one of the most important centres of glass manufacture and trade in Western Europe, little is known about the origins of the Venetian glassmaking. Some archaeologists suggest there is a continuity in the history of glass making, in its transplantation from the Roman centres of the mainland (Altino and Aquileia), first to some islands of the lagoon, and later to the town. Some others, instead, think that there was no continuity at all and that the art of glassmaking was imported in Venice from the Islamic glass factories of the Middle East. Of great help in answering this and other technological questions is the information about the composition of ancient glass from well-dated excavations that allows to conclude on the early technology, sources of raw materials and long-distance trade. Some significant glass findings, including fragments of pots used for glass melting, were found on the island of Torcello and, more recently, in two emergency excavations in the historic centre of Venice. In this paper, the chemical composition of a large set of glass findings (and related materials) from the Venetian lagoon dating from the 7th to the 13th centuries is determined by X-ray microanalysis in order to throw new light on the glassmaking technology in the early centuries of the Venetian tradition. The results show that in this period there occurred a gradual transition from the Roman technique (a two-ingredient formulation with silica-lime sand and natron as a fluxer), towards the use of silica sand and soda plant ash. There is evidence, therefore, for a production continuity with the Roman period (melting pots and glass scraps with a natron-based composition), yet restricted to transparent blown items. No evidence was found for a local production of glass tesserae for the mosaics of the church of St. Maria Assunta in Torcello.  相似文献   

Have the poor found their own appropriate     

Lúcia Radler dos Guaranys  Cláudio de Moura Castro 《International Journal of Educational Development》1982,2(2):163-174

Correspondence schools in Brazil are entirely in the hands of private entrepreneurs and ignored, even despised, by official educators. Yet, as this paper shows, they can, —in many cases, do—, provide helpful education for those who have no other access to educational opportunity. Indeed, they appear to offer the most equal form of opportunity. Accompanying their benefits, however, are many imperfections and abuses. The paper identifies five areas where government intervention could help both the public and the correspondence schools, without stifling their current vitality.  相似文献   

LABRADOR: Efficiently publishing relational databases on the web by using keyword-based query interfaces     

Filipe Mesquita  Altigran S. da Silva  Edleno S. de Moura  Pável Calado  Alberto H.F. Laender 《Information processing & management》2007

A vast amount of valuable information, produced and consumed by people and institutions, is currently stored in relational databases. For many purposes, there is an ever increasing demand for having these databases published on the Web, so that users can query the data available in them. An important requirement for this to happen is that query interfaces must be as simple and intuitive as possible. In this paper we present LABRADOR, a system for efficiently publishing relational databases on the Web by using a simple text box query interface. The system operates by taking an unstructured keyword-based query posed by a user and automatically deriving an equivalent SQL query that fits the user’s information needs, as expressed by the original query. The SQL query is then sent to a DBMS and its results are processed by LABRADOR to create a relevance-based ranking of the answers. Experiments we present show that LABRADOR can automatically find the most suitable SQL query in more than 75% of the cases, and that the overhead introduced by the system in the overall query processing time is almost insignificant. Furthermore, the system operates in a non-intrusive way, since it requires no modifications to the target database schema.  相似文献